Peptide Library/Fat Loss & Metabolic/BAM15

BAM15

Research ChemicalModerate Research

Also known as: Mitochondrial Uncoupler BAM15

A mitochondrial protonophore uncoupler that dissipates the proton gradient to burn calories as heat, promoting fat loss without affecting body temperature or food intake.

Overview

BAM15 is a mitochondrial uncoupling agent that works by partially dissipating the proton gradient across the inner mitochondrial membrane. Normally, this gradient drives ATP synthesis, but when uncoupled, the energy is released as heat instead. This effectively increases the body's metabolic rate and caloric expenditure. Unlike older uncouplers like DNP (2,4-dinitrophenol), BAM15 is selective for mitochondria and does not uncouple the plasma membrane, making it significantly safer with a much wider therapeutic window.

In preclinical studies, BAM15 has demonstrated impressive fat loss results — reducing body fat mass by up to 20% without affecting lean mass, food intake, or core body temperature. It also improves insulin sensitivity, reduces hepatic steatosis (fatty liver), and decreases inflammation.

Mechanism of Action

Selectively inserts into the inner mitochondrial membrane and facilitates proton leak across the membrane, partially uncoupling oxidative phosphorylation from ATP synthesis. This increases substrate oxidation (fatty acids and glucose) to maintain the proton gradient, effectively burning more calories. Unlike DNP, BAM15 does not uncouple the plasma membrane proton gradient.

Key Benefits

Significant fat loss without muscle loss

Increased metabolic rate

Improved insulin sensitivity

Reduced liver fat (hepatic steatosis)

Anti-inflammatory effects

Does not affect body temperature at therapeutic doses

Potential Side Effects

Mild increase in body heat sensation

Potential sweating

GI discomfort at high doses

Caution with thyroid medications

Common Stacks

This peptide is commonly combined with the following compounds for synergistic effects:

5-Amino-1MQL-CarnitineAOD-9604AICAR

Known Interactions

The following interactions have been documented for BAM15. Always consult a healthcare professional before combining compounds.

Synergistic (1)

L-CarnitineSynergistic

BAM15 uncouples mitochondria to burn fat as heat while L-Carnitine shuttles fatty acids into mitochondria. Complementary fat oxidation mechanisms.

View all compound interactions

Scientific References

BAM15-Mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control

Alexopoulos SJ, Chen SY, Zhang Y, et al.

EMBO Molecular Medicine (2020)

Mitochondrial Uncoupler BAM15 Reverses Diet-Induced Obesity and Insulin Resistance

Kenwood BM, Weaver JL, Bajwa A, et al.

Nature Communications (2014)

Quick Reference

Typical Dose

50mg-150mg

Frequency

1-2x daily AM/Mid Day

Route

Oral or injectable

Half-Life

~4-6 hours

Cycle Length

4-8 weeks; 5 on 2 off or daily, followed by 4-8 weeks recovery

FDA Status

Research compound — not FDA approved. Preclinical data only.

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Use our reconstitution calculator to determine exact syringe measurements.

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This information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.

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