DHEA
Also known as: Dehydroepiandrosterone · DHEA-S · Prasterone
The most abundant circulating steroid hormone and a precursor to both testosterone and estrogen, declining significantly with age and linked to immune function, mood, and longevity.
Overview
Dehydroepiandrosterone (DHEA) is a steroid hormone produced primarily by the adrenal glands, with smaller amounts produced by the gonads and brain. It serves as a crucial precursor hormone — the body converts DHEA into both androgens (testosterone, DHT) and estrogens (estradiol, estrone) depending on tissue-specific enzyme expression. DHEA levels peak in the mid-20s and decline steadily, falling by 80-90% by age 70-80, a process termed "adrenopause." DHEA supplementation has gained significant attention in the longevity and optimization communities. Research suggests benefits for immune function (enhances Th1 immunity), bone density, body composition, mood, cognitive function, and sexual health.
DHEA also has direct effects independent of its conversion to sex hormones — it modulates GABA-A and NMDA receptors, has anti-cortisol properties, and influences insulin sensitivity. The sulfated form (DHEA-S) serves as a circulating reservoir with a much longer half-life. Intravaginal DHEA (Prasterone/Intrarosa) is FDA-approved for vulvovaginal atrophy.
Mechanism of Action
Serves as a precursor for peripheral conversion to androgens and estrogens via tissue-specific steroidogenic enzymes (3β-HSD, 17β-HSD, aromatase). Directly modulates GABA-A receptors (negative modulator), NMDA receptors (positive modulator), and sigma-1 receptors. Antagonizes cortisol at the glucocorticoid receptor level. Enhances IGF-1 signaling.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Known Interactions
The following interactions have been documented for DHEA. Always consult a healthcare professional before combining compounds.
Synergistic (1)
DHEA serves as a precursor hormone that supports overall hormonal balance. Can complement TRT by supporting adrenal function and providing additional androgen precursors.
Scientific References
Quick Reference
Typical Dose
25-50 mg/day (men); 10-25 mg/day (women); 5-10 mg (topical)
Frequency
Once daily, typically in the morning
Route
Oral capsule; topical cream; sublingual; intravaginal (Prasterone)
Half-Life
~15-38 minutes (DHEA); ~7-10 hours (DHEA-S)
Cycle Length
Ongoing with regular monitoring of DHEA-S, testosterone, and estradiol levels
FDA Status
Available as OTC supplement; Prasterone (Intrarosa) FDA-approved for vulvovaginal atrophy
Need to calculate dosing?
Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.
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