Human Growth Hormone (HGH)

Human Growth Hormone (HGH/Somatropin) is a 191-amino acid protein produced by the anterior pituitary gland. It is the master regulatory hormone for growth, cellular repair, metabolism, and body composition. HGH secretion follows a pulsatile pattern, with the largest pulses occurring during deep sleep and after intense exercise. Production peaks during puberty and declines approximately 14% per decade after age 30 — a process called somatopause. Recombinant HGH (rHGH) is FDA-approved for adult growth hormone deficiency, and its use in anti-aging and wellness protocols has grown substantially.

HGH acts both directly (via GH receptors) and indirectly through stimulating IGF-1 production in the liver. Its effects include increased fat oxidation (particularly visceral fat), improved lean body mass, enhanced collagen synthesis, better sleep quality, improved skin elasticity, and accelerated recovery from injuries. In the longevity space, HGH is used at lower 'replacement' doses (1-2 IU/day) rather than the higher doses used in performance contexts. Many practitioners prefer GH secretagogues (CJC-1295, Ipamorelin) to stimulate natural pulsatile release, but direct HGH replacement remains the gold standard for confirmed GH deficiency.