HCG

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced during pregnancy by the placenta. Its alpha subunit is identical to LH (luteinizing hormone), allowing it to bind to and activate LH receptors in the testes. In men's health optimization, HCG is primarily used alongside Testosterone Replacement Therapy to maintain testicular size, intratesticular testosterone (ITT) production, fertility (spermatogenesis), and the production of other testicular hormones and neurosteroids. Without HCG during TRT, the HPG axis suppression caused by exogenous testosterone leads to testicular atrophy and cessation of sperm production. HCG maintains Leydig cell function and the local production of testosterone, estradiol, progesterone, DHEA, and other important intratesticular metabolites.

Many men report improved mood, libido, and sense of well-being when HCG is added to their TRT protocol, likely due to the maintenance of these intratesticular hormones. HCG is also used in fertility protocols and as monotherapy for secondary hypogonadism.