Hexarelin

Hexarelin is a synthetic hexapeptide growth hormone releasing peptide (GHRP) that produces one of the strongest GH releases of any peptide in its class. It acts on both the pituitary gland and the hypothalamus to stimulate growth hormone secretion. What makes Hexarelin particularly interesting beyond its GH-releasing capacity is its demonstrated cardioprotective effects. Research has shown that Hexarelin can protect cardiac tissue from ischemia-reperfusion injury, improve cardiac function in heart failure models, and reduce cardiac fibrosis.

These effects appear to be mediated through cardiac GHS receptors independent of GH release. However, Hexarelin is known to cause desensitization with prolonged use — GH release diminishes after approximately 4-6 weeks of continuous administration. It also elevates cortisol and prolactin more than Ipamorelin, making it less selective but more potent.