Oxandrolone
Also known as: Anavar · Oxandrin · Var
A mild oral anabolic steroid with a high anabolic-to-androgenic ratio, used medically for muscle wasting and increasingly studied for its effects on body composition and recovery.
Overview
Oxandrolone (brand name Anavar) is a synthetic anabolic-androgenic steroid (AAS) derived from dihydrotestosterone (DHT). It is considered one of the mildest oral anabolic steroids, with an anabolic-to-androgenic ratio of approximately 322-630:24 (compared to testosterone's 100:100). This favorable ratio means it promotes significant anabolic (muscle-building, fat-reducing) effects with relatively low androgenic (masculinizing) side effects. Medically, oxandrolone is FDA-approved for promoting weight gain after severe weight loss from surgery, chronic infections, trauma, or prolonged corticosteroid use. It is also used in burn recovery, Turner syndrome, and HIV-associated wasting.
In the optimization community, it is valued for its ability to promote lean muscle gain, reduce visceral fat, increase strength, and improve recovery — all with a relatively mild side effect profile compared to other AAS. Unlike many oral steroids, oxandrolone is not 17-alpha-alkylated in the traditional sense (it has a modified A-ring), making it less hepatotoxic, though liver monitoring is still recommended.
Mechanism of Action
Binds to androgen receptors with high affinity, promoting protein synthesis and nitrogen retention. As a DHT derivative, it cannot aromatize to estrogen. Increases phosphocreatine synthesis for improved ATP regeneration. Enhances lipolysis through AR-mediated effects on adipose tissue. Upregulates androgen receptor density in skeletal muscle. Reduces SHBG, increasing free testosterone.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Known Interactions
The following interactions have been documented for Oxandrolone. Always consult a healthcare professional before combining compounds.
Use Caution (2)
Both are anabolic agents. Combined use amplifies anabolic effects but also increases liver stress (oxandrolone), lipid disruption, and HPG axis suppression. Monitor bloodwork closely.
Both have anabolic effects and potential liver impact. YK-11 is a myostatin inhibitor with steroidal structure, and oxandrolone is a 17-alpha alkylated steroid. Monitor liver enzymes.
Scientific References
Quick Reference
Typical Dose
10-20 mg/day (therapeutic); 20-50 mg/day (men, optimization); 5-10 mg/day (women)
Frequency
Split into 2 doses daily (due to ~9-hour half-life)
Route
Oral tablet
Half-Life
~9 hours
Cycle Length
6-8 weeks; requires post-cycle therapy (PCT) if used without TRT base
FDA Status
FDA approved (Oxandrin) for weight gain in catabolic conditions
Need to calculate dosing?
Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.
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