Peptide Library/Supplements & Nutraceuticals/CDP-Choline

CDP-Choline

Research ChemicalExtensive Research

Also known as: Citicoline · Cytidine Diphosphate-Choline

A naturally occurring nootropic that provides both choline and cytidine for acetylcholine synthesis, neuroprotection, and enhanced phospholipid membrane repair.

Overview

CDP-Choline (Citicoline) is an endogenous nucleotide that serves as an intermediate in the biosynthesis of phosphatidylcholine, a major component of neuronal cell membranes. When taken as a supplement, CDP-Choline is hydrolyzed into choline and cytidine, which are then absorbed and recombined in the brain. The choline component supports acetylcholine synthesis, while cytidine is converted to uridine, which enhances synaptic plasticity and phospholipid synthesis. CDP-Choline has been extensively studied in clinical trials for stroke recovery, traumatic brain injury, cognitive decline, and glaucoma.

It is approved as a prescription drug in many countries for neurological conditions. In health optimization, it is valued for its dual mechanism of providing both the neurotransmitter precursor (choline) and the membrane repair substrate (cytidine/uridine).

Mechanism of Action

Hydrolyzed to choline and cytidine in the gut. Choline supports acetylcholine synthesis via ChAT. Cytidine is converted to uridine, which enhances phosphatidylcholine synthesis for membrane repair. Also increases dopamine receptor density in the striatum and modulates glutamate release.

Key Benefits

Enhanced memory and cognitive function

Neuroprotection after brain injury

Improved attention and focus

Supports neuronal membrane repair

May increase dopamine receptor density

Synergistic with other nootropics

Potential Side Effects

Headache (uncommon)

Insomnia if taken late

GI discomfort at high doses

Very well-tolerated overall

Common Stacks

This peptide is commonly combined with the following compounds for synergistic effects:

Alpha GPCSemax9-ME-BCSelank

Known Interactions

The following interactions have been documented for CDP-Choline. Always consult a healthcare professional before combining compounds.

Use Caution (1)

Alpha GPCCaution

Both are choline sources. Using together may cause excessive acetylcholine, leading to headaches, GI distress, or cholinergic side effects. Choose one.

View all compound interactions

Scientific References

Citicoline in the Treatment of Acute Ischaemic Stroke: An International, Randomised, Multicentre, Placebo-Controlled Study

Davalos A, Castillo J, Alvarez-Sabin J, et al.

Lancet (2012)

Citicoline: Pharmacological and Clinical Review

Secades JJ, Lorenzo JL

Methods and Findings in Experimental and Clinical Pharmacology (2006)

Quick Reference

Typical Dose

200mg-600mg

Frequency

1-2x daily

Route

Oral or injectable

Half-Life

~56 hours (cytidine component)

Cycle Length

Can be used continuously; 5 on 2 off or daily

FDA Status

Available as dietary supplement in the US. Prescription medication in Europe and Japan for neurological conditions.

Need to calculate dosing?

Use our reconstitution calculator to determine exact syringe measurements.

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This information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.

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