Melanotan 1
Also known as: Afamelanotide · MT-1 · Scenesse · NDP-alpha-MSH
An FDA-approved synthetic melanocortin analog that stimulates melanin production for UV-independent tanning and photoprotection in certain skin conditions.
Overview
Melanotan 1 (Afamelanotide) is a synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that activates melanocortin 1 receptors (MC1R) on melanocytes, stimulating melanin production and providing UV-independent tanning. Unlike Melanotan 2, MT-1 is highly selective for MC1R and does not significantly activate other melanocortin receptors, giving it a cleaner side effect profile without the sexual, appetite, or cardiovascular effects associated with MT-2. Afamelanotide has been FDA-approved (as Scenesse) for the treatment of erythropoietic protoporphyria (EPP), a rare genetic condition causing extreme photosensitivity. In health optimization, Melanotan 1 is used for its photoprotective properties — the increased melanin provides natural UV protection, potentially reducing skin cancer risk and sun damage.
Mechanism of Action
Selectively binds and activates melanocortin 1 receptor (MC1R) on melanocytes. MC1R activation increases cAMP, which activates MITF (microphthalmia-associated transcription factor), upregulating tyrosinase and other melanin synthesis enzymes. Promotes eumelanin (brown/black protective pigment) production over pheomelanin.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Known Interactions
The following interactions have been documented for Melanotan 1. Always consult a healthcare professional before combining compounds.
Contraindicated (1)
Both stimulate melanogenesis through MC1R. Using together provides no additional benefit and increases risk of nausea, facial flushing, and mole darkening.
Scientific References
Quick Reference
Typical Dose
250mcg-1000mcg
Frequency
1x daily
Route
Subcutaneous injection (or implant for Scenesse)
Half-Life
~30 minutes (but melanin effects persist for weeks)
Cycle Length
4-12 weeks (then maintenance); daily use
FDA Status
FDA approved as Scenesse (afamelanotide implant) for erythropoietic protoporphyria. Injectable form not FDA approved for cosmetic tanning.
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Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.