Melanotan 2
Also known as: MT-2 · MT-II · Barbie Drug
A non-selective melanocortin agonist that produces rapid tanning, appetite suppression, and enhanced sexual function through activation of multiple MC receptors.
Overview
Melanotan 2 (MT-2) is a synthetic cyclic peptide analog of alpha-melanocyte-stimulating hormone that activates multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R). This broad receptor activation profile produces a range of effects: MC1R activation stimulates melanin production and tanning; MC4R activation suppresses appetite and enhances sexual arousal; and MC3R activation influences energy homeostasis. MT-2 produces rapid, pronounced tanning even with minimal UV exposure and has potent effects on sexual function in both men and women. It was the original compound from which PT-141 (bremelanotide) was derived for sexual dysfunction treatment.
Due to its non-selective nature, MT-2 produces more side effects than Melanotan 1, including nausea, facial flushing, and potential cardiovascular effects. It remains one of the most widely used cosmetic peptides globally despite not being approved for this purpose.
Mechanism of Action
Non-selective agonist of melanocortin receptors MC1R (tanning), MC3R (energy homeostasis), MC4R (appetite suppression, sexual arousal), and MC5R (sebaceous gland function). MC1R activation increases eumelanin synthesis. MC4R activation in the hypothalamus reduces food intake and in the spinal cord enhances erectile function.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Known Interactions
The following interactions have been documented for Melanotan 2. Always consult a healthcare professional before combining compounds.
Contraindicated (1)
Both stimulate melanogenesis through MC1R. Using together provides no additional benefit and increases risk of nausea, facial flushing, and mole darkening.
Use Caution (1)
PT-141 (bremelanotide) is derived from Melanotan 2. Both act on melanocortin receptors. Using together may cause excessive nausea, blood pressure changes, and flushing.
Scientific References
Quick Reference
Typical Dose
250mcg-1000mcg
Frequency
1x daily
Route
Subcutaneous injection
Half-Life
~1-2 hours (but melanin effects persist)
Cycle Length
4-12 weeks (loading), then maintenance as needed
FDA Status
Research compound — not FDA approved. PT-141 (derived from MT-2) is FDA approved for HSDD.
Need to calculate dosing?
Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.