NAD+ (Injectable)
Also known as: NAD+ IV · NAD+ Injection · Nicotinamide Adenine Dinucleotide Injectable · NAD+ SubQ
Direct injectable form of NAD+ that bypasses oral bioavailability limitations, rapidly restoring cellular NAD+ levels to support mitochondrial function, DNA repair, and sirtuin activation.
Overview
Injectable NAD+ delivers nicotinamide adenine dinucleotide directly into the body via subcutaneous or intravenous routes, bypassing the significant bioavailability limitations of oral NAD+ precursors like NMN and NR. NAD+ is a critical coenzyme found in every living cell, essential for over 500 enzymatic reactions including energy metabolism, DNA repair, gene expression, and cellular signaling. NAD+ levels decline approximately 50% between ages 40 and 60, contributing to mitochondrial dysfunction, impaired DNA repair, decreased sirtuin activity, and accelerated aging. While oral precursors (NMN, NR) must undergo multi-step conversion to NAD+, injectable NAD+ provides the molecule directly, achieving rapid and significant elevation of tissue NAD+ levels. IV NAD+ infusions typically take 2-4 hours due to the need for slow administration to minimize side effects, while subcutaneous injections offer a more practical daily option. Clinical applications include anti-aging protocols, neurodegenerative support, addiction recovery, chronic fatigue, and metabolic optimization.
Many practitioners report that injectable NAD+ produces more noticeable effects than oral precursors, including improved energy, mental clarity, and exercise recovery.
Mechanism of Action
NAD+ serves as an essential cofactor for three major enzyme families: Sirtuins (SIRT1-7) — NAD+-dependent deacetylases that regulate gene expression, DNA repair, mitochondrial biogenesis, and inflammation. PARPs (Poly ADP-Ribose Polymerases) — consume NAD+ during DNA damage repair. CD38/CD157 — NADases that increase with age and are major drivers of NAD+ decline. Injectable NAD+ directly replenishes the cellular NAD+ pool, immediately supporting these pathways without requiring biosynthetic conversion steps.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Scientific References
Quick Reference
Typical Dose
SubQ: 50-200mg daily. IV: 250-1000mg per session (infused over 2-4 hours)
Frequency
SubQ: Daily to 3x/week. IV: Weekly to monthly
Route
Subcutaneous injection or intravenous infusion
Half-Life
~30-45 minutes (plasma), but tissue effects persist much longer
Cycle Length
Ongoing — many protocols run 3-6 months with periodic breaks
FDA Status
Not FDA approved as a drug; used as a compounded preparation
Need to calculate dosing?
Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.
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