Pinealon
Also known as: EDR Peptide · Glu-Asp-Arg
A short bioregulatory peptide (EDR) that supports pineal gland function, melatonin synthesis, circadian rhythm regulation, and neuroprotection.
Overview
Pinealon is a tripeptide (Glu-Asp-Arg, or EDR) belonging to the Khavinson peptide bioregulator family, designed to support pineal gland function and melatonin synthesis. The pineal gland is the master circadian clock regulator, producing melatonin in response to darkness and orchestrating sleep-wake cycles, hormone rhythms, and seasonal biological processes. Pineal function declines significantly with age, contributing to sleep disruption, hormonal dysregulation, and accelerated aging. Pinealon has been shown to penetrate cell membranes and interact with DNA, potentially regulating gene expression related to melatonin synthesis and neuroprotection.
In clinical studies conducted primarily in Russia, Pinealon demonstrated improvements in cognitive function, sleep quality, and biomarkers of aging in elderly patients. It is part of a broader class of short peptide bioregulators developed by Professor Vladimir Khavinson.
Mechanism of Action
Penetrates cell membranes and interacts with specific DNA sequences to regulate gene expression. Upregulates enzymes involved in melatonin synthesis (AANAT, HIOMT). Provides neuroprotective effects through antioxidant mechanisms and modulation of apoptotic pathways. May support telomere maintenance.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Known Interactions
The following interactions have been documented for Pinealon. Always consult a healthcare professional before combining compounds.
Synergistic (2)
Pinealon supports pineal gland function and melatonin regulation while DSIP directly promotes delta-wave sleep. Complementary sleep optimization.
Epithalon activates telomerase to maintain telomere length while Pinealon supports pineal gland function. Both are Khavinson peptides targeting aging from different angles.
Scientific References
Quick Reference
Typical Dose
2mg-5mg
Frequency
1x daily AM
Route
Oral (sublingual) or injectable
Half-Life
~2-4 hours
Cycle Length
10-20 days; daily use, followed by 3-6 months recovery
FDA Status
Research compound — not FDA approved. Studied primarily in Russian clinical trials.
Need to calculate dosing?
Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.
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