SLU-PP-332
Also known as: ERR Agonist · Exercise Mimetic
A novel ERR (estrogen-related receptor) agonist that mimics the molecular effects of exercise, enhancing endurance, fat oxidation, and muscle fiber type switching.
Overview
SLU-PP-332 is a small molecule agonist of estrogen-related receptors (ERRs) — a family of orphan nuclear receptors that are key regulators of energy metabolism and mitochondrial function. ERRs are naturally activated by exercise and play a central role in the adaptive response to endurance training, including mitochondrial biogenesis, fatty acid oxidation, and the switch from fast-twitch (glycolytic) to slow-twitch (oxidative) muscle fibers. In preclinical research published in 2023, SLU-PP-332 demonstrated remarkable exercise-mimetic effects: treated mice showed significantly enhanced running endurance, increased oxidative muscle fiber content, improved fat metabolism, and resistance to diet-induced obesity — all without actual exercise. This compound represents a new class of exercise mimetics distinct from AICAR and Cardarine, targeting a different molecular pathway.
Mechanism of Action
Activates estrogen-related receptors (ERRalpha, ERRbeta, ERRgamma), which translocate to the nucleus and upregulate genes involved in oxidative phosphorylation, fatty acid oxidation, mitochondrial biogenesis, and muscle fiber type specification. Promotes the conversion of type IIb (fast glycolytic) to type IIa/I (slow oxidative) muscle fibers.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Known Interactions
The following interactions have been documented for SLU-PP-332. Always consult a healthcare professional before combining compounds.
Synergistic (1)
Cardarine (PPARδ agonist) and SLU-PP-332 (ERRα/γ agonist) both enhance endurance through complementary nuclear receptor pathways. Powerful exercise mimetic stack.
Scientific References
Quick Reference
Typical Dose
500mcg-1500mcg
Frequency
2-3x daily AM/Mid/PM
Route
Subcutaneous injection or oral
Half-Life
~4-8 hours
Cycle Length
8-16 weeks; daily use, followed by 4 weeks recovery
FDA Status
Research compound — not FDA approved. Preclinical data only (published 2023).
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Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.
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