TB-500
Also known as: Thymosin Beta-4 · TB4
A synthetic version of the naturally occurring 43-amino-acid peptide Thymosin Beta-4, essential for tissue repair, cell migration, and reducing inflammation.
Overview
TB-500 is a synthetic fragment of Thymosin Beta-4 (TB4), a naturally occurring 43-amino-acid peptide present in virtually all human and animal cells. Thymosin Beta-4 is one of the most abundant intracellular peptides and plays a critical role in tissue repair, cell migration, and new blood vessel formation. TB-500 contains the active region of TB4 responsible for its healing properties. The peptide works primarily by upregulating actin, a cell-building protein that is essential for cell migration, proliferation, and differentiation — all critical processes in wound healing and tissue repair.
TB-500 has a unique molecular structure that gives it high mobility and the ability to travel long distances through tissues, meaning it can exert systemic healing effects regardless of injection site. This is a key advantage over BPC-157, which tends to work more locally. TB-500 has shown particular promise in healing slow-to-recover injuries like tendon and ligament damage, and has been widely used in equine medicine for decades. It also demonstrates anti-inflammatory, anti-fibrotic, and hair regrowth properties.
Mechanism of Action
Upregulates actin polymerization, promoting cell migration and proliferation. Activates the Akt signaling pathway for cell survival. Reduces inflammatory cytokines (IL-1β, TNF-α). Promotes angiogenesis through VEGF upregulation. Inhibits fibrosis by reducing TGF-β1 signaling.
Key Benefits
Potential Side Effects
Common Stacks
This compound is commonly combined with the following for synergistic effects:
Known Interactions
The following interactions have been documented for TB-500. Always consult a healthcare professional before combining compounds.
Synergistic (2)
The most popular healing stack. BPC-157 targets local tissue repair (gut, tendons, ligaments) while TB-500 provides systemic healing through cell migration and angiogenesis.
TB-500's cell migration and angiogenesis combined with GHK-Cu's collagen remodeling provides excellent wound healing and skin repair support.
TB-500 Fragment vs. Full Sequence
When purchasing TB-500, you will encounter two distinct versions. Understanding the difference is critical for achieving your desired research outcomes.
TB-500 Fragment 17-23
7 amino acids
Sequence:
LKKTETQ
This is the isolated active domain of the Thymosin Beta-4 molecule. It contains only the specific 7-amino-acid sequence responsible for actin binding and cell migration.
Best For
Targeted healing of specific acute injuries (muscle tears, tendon strains) where localized cell migration is the primary goal.
Thymosin Beta-4 (Full Sequence)
43 amino acids
Sequence:
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
This is the complete, naturally occurring 43-amino-acid peptide. It contains the 17-23 fragment but also includes other domains that provide additional biological functions.
Best For
Systemic healing, chronic inflammation, cardiovascular support, and comprehensive tissue regeneration.
Side-by-Side Comparison
| Aspect | TB-500 Fragment 17-23 | Thymosin Beta-4 (Full Sequence) |
|---|---|---|
| Molecular Weight | Very low (7 amino acids) | Higher (43 amino acids) |
| Primary Action | Actin upregulation & cell migration | Comprehensive tissue repair & anti-inflammation |
| Systemic Effects | Moderate | High |
| Cost | Generally lower | Generally higher due to complex synthesis |
Recommendation: For a specific, localized injury like a torn muscle or sprained tendon, the 17-23 Fragment is highly effective and cost-efficient. For systemic issues, chronic inflammation, or comprehensive anti-aging protocols, the Full 43-Amino Acid Sequence is superior due to its broader range of biological activities.
Which Form Should I Choose?
Answer a few quick questions to get a personalized recommendation based on your research needs.
Scientific References
Quick Reference
Typical Dose
Loading: 2-5 mg subcutaneous, 2x/week for 4-6 weeks. Maintenance: 2 mg/week (men and women).
Frequency
2x/week (loading phase), then 1x/week (maintenance)
Route
Subcutaneous or intramuscular injection
Half-Life
~4-6 hours (but effects persist due to cellular uptake)
Cycle Length
4-6 week loading, then 2-4 week maintenance
FDA Status
Not FDA approved; research chemical
Need to calculate dosing?
Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any compound. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.
Related Compounds in Healing & Recovery
BPC-157
A 15-amino-acid peptide derived from human gastric juice that demonstrates remarkable healing properties across virtually every tissue type studied.
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A naturally occurring copper-binding tripeptide that activates over 4,000 genes, promoting tissue remodeling, anti-aging, and regeneration at the genetic level.
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A tripeptide fragment of alpha-melanocyte stimulating hormone (α-MSH) with potent anti-inflammatory and antimicrobial properties, especially for gut health.
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