Peptide Library/Healing & Recovery/ARA-290

ARA-290

InvestigationalModerate Research

Also known as: Cibinetide · Innate Repair Receptor Agonist

A non-erythropoietic EPO-derived peptide that activates the innate repair receptor, providing tissue-protective and anti-inflammatory effects without blood thickening.

Overview

ARA-290 (Cibinetide) is an 11-amino acid peptide derived from the tissue-protective domain of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR). Unlike EPO itself, ARA-290 does not stimulate red blood cell production or cause blood thickening. The innate repair receptor is expressed on a wide variety of tissues and is upregulated during injury and inflammation. When activated by ARA-290, it triggers anti-inflammatory, anti-apoptotic, and tissue-repair signaling cascades.

Clinical trials have demonstrated ARA-290's efficacy in treating small fiber neuropathy, sarcoidosis-related neuropathy, and chronic pain conditions.

Mechanism of Action

Binds to the innate repair receptor (IRR), a heterodimer of EPO-R and beta-cR. Activates JAK2/STAT5, PI3K/Akt, and NF-kB modulation pathways. Reduces pro-inflammatory cytokine production, inhibits apoptosis in stressed cells, promotes angiogenesis, and stimulates tissue repair.

Key Benefits

Neuroprotection and nerve repair

Anti-inflammatory effects

Improved small fiber neuropathy symptoms

Tissue repair and wound healing

Potential metabolic improvements

No blood-thickening side effects

Potential Side Effects

Injection site reactions

Mild headache (uncommon)

Generally well-tolerated in clinical trials

Common Stacks

This peptide is commonly combined with the following compounds for synergistic effects:

BPC-157TB-500SS-31GHK-Cu

Known Interactions

The following interactions have been documented for ARA-290. Always consult a healthcare professional before combining compounds.

Synergistic (1)

BPC-157Synergistic

ARA-290 (innate repair receptor agonist) + BPC-157 (tissue repair peptide) provides multi-pathway tissue repair, particularly useful for neuropathy and chronic injuries.

View all compound interactions

Scientific References

ARA 290 Improves Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss

Heij L, Dahan A, Hoitsma E

Molecular Medicine (2012)

Cibinetide for Treatment of Sarcoidosis-Associated Small Fiber Neuropathy: A Randomized Controlled Trial

Dahan A, Dunne A, Swartjes M, et al.

Pain (2013)

Quick Reference

Typical Dose

1mg-4mg

Frequency

1x daily

Route

Subcutaneous injection

Half-Life

~2-3 hours

Cycle Length

4-12 weeks; 5 on 2 off or daily

FDA Status

Investigational — completed multiple Phase 2 clinical trials. Not yet FDA approved.

Need to calculate dosing?

Use our reconstitution calculator to determine exact syringe measurements.

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This information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.

Related Peptides in Healing & Recovery

BPC-157

A 15-amino-acid peptide derived from human gastric juice that demonstrates remarkable healing properties across virtually every tissue type studied.

TB-500

A synthetic version of the naturally occurring 43-amino-acid peptide Thymosin Beta-4, essential for tissue repair, cell migration, and reducing inflammation.

GHK-Cu

A naturally occurring copper-binding tripeptide that activates over 4,000 genes, promoting tissue remodeling, anti-aging, and regeneration at the genetic level.