Glutathione
Also known as: GSH · L-Glutathione · Reduced Glutathione
The body's master antioxidant — a tripeptide essential for detoxification, immune function, and protection against oxidative stress, delivered via injection for maximum bioavailability.
Overview
Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine that serves as the body's most important intracellular antioxidant and detoxification molecule. Present in every cell, glutathione protects against oxidative damage, supports phase II liver detoxification, maintains immune function, and recycles other antioxidants like vitamins C and E. Glutathione levels naturally decline with age, stress, toxin exposure, and chronic illness, contributing to accelerated aging and disease susceptibility. Oral glutathione supplementation has poor bioavailability due to degradation in the GI tract, making injectable administration the preferred route for achieving therapeutic tissue levels.
Injectable glutathione is widely used in health optimization for detoxification support, immune enhancement, skin health, and as a foundational antioxidant in comprehensive wellness protocols.
Mechanism of Action
Acts as the primary intracellular antioxidant by donating electrons to neutralize reactive oxygen and nitrogen species. Conjugates xenobiotics and toxins via glutathione S-transferase enzymes for excretion. Maintains the thiol redox state of proteins. Regenerates oxidized vitamins C and E. Supports T-cell proliferation and NK cell activity.
Key Benefits
Potential Side Effects
Common Stacks
This peptide is commonly combined with the following compounds for synergistic effects:
Known Interactions
The following interactions have been documented for Glutathione. Always consult a healthcare professional before combining compounds.
Synergistic (3)
GHK-Cu's tissue remodeling and anti-aging effects paired with glutathione's master antioxidant protection creates a powerful skin health and anti-aging protocol.
Glutathione provides master antioxidant protection while NAD+ supports cellular energy and repair. Foundational cellular health stack.
Glutathione supports detoxification while B12 supports methylation. Both are essential for phase II liver detoxification pathways.
Scientific References
Quick Reference
Typical Dose
200mg-400mg
Frequency
1x daily
Route
Intravenous or intramuscular injection
Half-Life
~1.6 hours (IV) / longer tissue retention
Cycle Length
Can be used continuously; 3 days a week is common
FDA Status
Available as compounded injectable. Generally recognized as safe (GRAS) as a supplement.
Need to calculate dosing?
Use our reconstitution calculator to determine exact syringe measurements.
Open CalculatorThis information is for educational purposes only. Consult a qualified healthcare professional before using any peptide. Dosing information reflects commonly reported protocols and may not be appropriate for everyone.
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